Safari profiles: possible to set profile in response to URL?

I’m interested in the new Profiles feature in Safari, and am thinking about it as a way to limit tracking.

I’d like to put, say, Facebook in a “penalty box” profile that I use only for visiting Facebook. It would be nice if this profile could be activated automatically when Facebook is my destination URL and switch back to whatever I was using before when it is not.

Any idea whether this is possible?

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